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Modelling the structures of frameshift-stimulatory pseudoknots from representative bat coronaviruses

Coronaviruses (CoVs) use −1 programmed ribosomal frameshifting stimulated by RNA pseudoknots in the viral genome to control expression of enzymes essential for replication, making CoV pseudoknots a promising target for anti-coronaviral drugs. Bats represent one of the largest reservoirs of CoVs and...

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Detalles Bibliográficos
Autores principales: Sekar, Rohith Vedhthaanth, Oliva, Patricia J., Woodside, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234561/
https://www.ncbi.nlm.nih.gov/pubmed/37205708
http://dx.doi.org/10.1371/journal.pcbi.1011124