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The kinesin light chain‐2, a target of mRNA stabilizing protein HuR, inhibits p53 protein phosphorylation to promote radioresistance in NSCLC

BACKGROUND: Radioresistance hinders radiotherapy for the treatment of lung cancer. Kinesin light chain‐2 (KLC2) has been found to be upregulated in lung cancer and also to be associated with poor prognosis. This study aimed to investigate the effect of KLC2 on radiosensitivity in lung cancer. METHOD...

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Detalles Bibliográficos
Autores principales: Qiao, Simiao, Jiang, Yuhang, Li, Na, Zhu, Xiaoxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234785/
https://www.ncbi.nlm.nih.gov/pubmed/37055376
http://dx.doi.org/10.1111/1759-7714.14886