Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR(CSTMLR) mutant protein: molecular modeling and free energy approach

EGFR (epidermal growth factor receptor), a surface protein on the cell, belongs to the tyrosine kinase family, responsible for cell growth and proliferation. Overexpression or mutation in the EGFR gene leads to various types of cancer, i.e., non-small cell lung cancer, breast, and pancreatic cancer....

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Detalles Bibliográficos
Autores principales: Saini, Ravi, Kumari, Sonali, Bhatnagar, Aditi, Singh, Amit, Mishra, Abha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235079/
https://www.ncbi.nlm.nih.gov/pubmed/37264083
http://dx.doi.org/10.1038/s41598-023-33065-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235079/
https://www.ncbi.nlm.nih.gov/pubmed/37264083
http://dx.doi.org/10.1038/s41598-023-33065-7

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