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Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFR(CSTMLR) mutant protein: molecular modeling and free energy approach
EGFR (epidermal growth factor receptor), a surface protein on the cell, belongs to the tyrosine kinase family, responsible for cell growth and proliferation. Overexpression or mutation in the EGFR gene leads to various types of cancer, i.e., non-small cell lung cancer, breast, and pancreatic cancer....
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235079/ https://www.ncbi.nlm.nih.gov/pubmed/37264083 http://dx.doi.org/10.1038/s41598-023-33065-7 |