Rio1 downregulates centromeric RNA levels to promote the timely assembly of structurally fit kinetochores

Kinetochores assemble on centromeres via histone H3 variant CENP-A and low levels of centromere transcripts (cenRNAs). The latter are ensured by the downregulation of RNA polymerase II (RNAPII) activity, and cenRNA turnover by the nuclear exosome. Using S. cerevisiae, we now add protein kinase Rio1...

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Detalles Bibliográficos
Autores principales: Smurova, Ksenia, Damizia, Michela, Irene, Carmela, Stancari, Stefania, Berto, Giovanna, Perticari, Giulia, Iacovella, Maria Giuseppina, D’Ambrosio, Ilaria, Giubettini, Maria, Philippe, Réginald, Baggio, Chiara, Callegaro, Elisabetta, Casagranda, Andrea, Corsini, Alessandro, Polese, Vincenzo Gentile, Ricci, Anna, Dassi, Erik, De Wulf, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235086/
https://www.ncbi.nlm.nih.gov/pubmed/37263996
http://dx.doi.org/10.1038/s41467-023-38920-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235086/
https://www.ncbi.nlm.nih.gov/pubmed/37263996
http://dx.doi.org/10.1038/s41467-023-38920-9

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