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High-pressure studies in the supercooled and glassy state of the strongly associated active pharmaceutical ingredient—ticagrelor

In this paper, the molecular dynamics at different thermodynamic conditions of hydrogen-bonded (H-bonded) active pharmaceutical ingredient—ticagrelor (TICA) have been investigated. Extensive high-pressure (HP) dielectric studies revealed surprising high sensitivity of the structural (α)-relaxation t...

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Detalles Bibliográficos
Autores principales: Jesionek, Paulina, Heczko, Dawid, Hachuła, Barbara, Kamiński, Kamil, Kamińska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235114/
https://www.ncbi.nlm.nih.gov/pubmed/37264074
http://dx.doi.org/10.1038/s41598-023-35772-7