Heterogeneity of voltage gated sodium current density between neurons decorrelates spiking and suppresses network synchronization in Scn1b null mouse models

Voltage gated sodium channels (VGSCs) are required for action potential initiation and propagation in mammalian neurons. As with other ion channel families, VGSC density varies between neurons. Importantly, sodium current (I(Na)) density variability is reduced in pyramidal neurons of Scn1b null mice...

Descripción completa

Detalles Bibliográficos
Autores principales: Hull, Jacob M., Denomme, Nicholas, Yuan, Yukun, Booth, Victoria, Isom, Lori L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235421/
https://www.ncbi.nlm.nih.gov/pubmed/37264112
http://dx.doi.org/10.1038/s41598-023-36036-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235421/
https://www.ncbi.nlm.nih.gov/pubmed/37264112
http://dx.doi.org/10.1038/s41598-023-36036-0

Ejemplares similares