SIRT3 alleviates imiquimod-induced psoriatic dermatitis through deacetylation of XBP1s and modulation of TLR7/8 inducing IL-23 production in macrophages

Current evidence suggests that IL-23, IL-6, and TNF-α play pivotal roles in the pathogenesis of psoriasis. Although it has been established that Sirtuin 3 (SIRT3) mediates the inflammatory process, the underlying mechanisms remain largely unclear. Herein, we substantiated that the inhibition or dele...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Meiliang, Zhuang, Haojun, Su, Yimin, Meng, Qinqin, Liu, Wanwen, Liu, Na, Wei, Min, Dai, Sheng-Ming, Deng, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235469/
https://www.ncbi.nlm.nih.gov/pubmed/37275851
http://dx.doi.org/10.3389/fimmu.2023.1128543

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235469/
https://www.ncbi.nlm.nih.gov/pubmed/37275851
http://dx.doi.org/10.3389/fimmu.2023.1128543

Ejemplares similares