EXT418, a novel long‐acting ghrelin, mitigates Lewis lung carcinoma induced cachexia in mice

BACKGROUND: Ghrelin is a potential therapy for cachexia due to its orexigenic properties and anabolic effects on muscle and fat. However, its clinical use is limited by the short half‐life of active (acylated) ghrelin (~11 min in humans). EXT418 is a novel long‐acting, constitutively active ghrelin...

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Detalles Bibliográficos
Autores principales: Kerr, Haiming L., Krumm, Kora, Lee, Ian (In‐gi), Anderson, Barbara, Christiani, Anthony, Strait, Lena, Breckheimer, Beatrice A., Irwin, Brynn, Jiang, Alice (Siyi), Rybachok, Artur, Chen, Amanda, Caeiro, Lucas, Dacek, Elizabeth, Hall, Daniel B., Kostyla, Caroline H., Hales, Laura M., Soliman, Tarik M., Garcia, Jose M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235874/
https://www.ncbi.nlm.nih.gov/pubmed/36942661
http://dx.doi.org/10.1002/jcsm.13211

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235874/
https://www.ncbi.nlm.nih.gov/pubmed/36942661
http://dx.doi.org/10.1002/jcsm.13211

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