Cargando…
Activation of skeletal muscle is controlled by a dual-filament mechano-sensing mechanism
Contraction of skeletal muscle is triggered by a transient rise in intracellular calcium concentration leading to a structural change in the actin-containing thin filaments that allows binding of myosin motors from the thick filaments. Most myosin motors are unavailable for actin binding in resting...
Autores principales: | Brunello, Elisabetta, Marcucci, Lorenzo, Irving, Malcolm, Fusi, Luca |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235942/ https://www.ncbi.nlm.nih.gov/pubmed/37216507 http://dx.doi.org/10.1073/pnas.2302837120 |
Ejemplares similares
-
Thick filament mechano-sensing is a calcium-independent regulatory mechanism in skeletal muscle
por: Fusi, L., et al.
Publicado: (2016) -
Activation of the myosin motors in fast‐twitch muscle of the mouse is controlled by mechano‐sensing in the myosin filaments
por: Hill, Cameron, et al.
Publicado: (2022) -
Myosin filament-based regulation of the dynamics of contraction in heart muscle
por: Brunello, Elisabetta, et al.
Publicado: (2020) -
Stress-dependent activation of myosin in the heart requires thin filament activation and thick filament mechanosensing
por: Park-Holohan, So-Jin, et al.
Publicado: (2021) -
Dependence of myosin filament structure on intracellular calcium concentration in skeletal muscle
por: Caremani, Marco, et al.
Publicado: (2023)