Starvation sensing by mycobacterial RelA/SpoT homologue through constitutive surveillance of translation

The stringent response, which leads to persistence of nutrient-starved mycobacteria, is induced by activation of the RelA/SpoT homolog (Rsh) upon entry of a deacylated-tRNA in a translating ribosome. However, the mechanism by which Rsh identifies such ribosomes in vivo remains unclear. Here, we show...

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Detalles Bibliográficos
Autores principales: Li, Yunlong, Majumdar, Soneya, Treen, Ryan, Sharma, Manjuli R., Corro, Jamie, Gamper, Howard B., Manjari, Swati R., Prusa, Jerome, Banavali, Nilesh K., Stallings, Christina L., Hou, Ya-Ming, Agrawal, Rajendra K., Ojha, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235957/
https://www.ncbi.nlm.nih.gov/pubmed/37216503
http://dx.doi.org/10.1073/pnas.2302006120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235957/
https://www.ncbi.nlm.nih.gov/pubmed/37216503
http://dx.doi.org/10.1073/pnas.2302006120

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