Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

The hypothesis that sustained G protein-coupled receptor (GPCR) signaling from endosomes mediates pain is based on studies with endocytosis inhibitors and lipid-conjugated or nanoparticle-encapsulated antagonists targeted to endosomes. GPCR antagonists that reverse sustained endosomal signaling and...

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Detalles Bibliográficos
Autores principales: Hegron, Alan, Peach, Chloe J., Tonello, Raquel, Seemann, Philipp, Teng, Shavonne, Latorre, Rocco, Huebner, Harald, Weikert, Dorothee, Rientjes, Jeanette, Veldhuis, Nicholas A., Poole, Daniel P., Jensen, Dane D., Thomsen, Alex R. B., Schmidt, Brian L., Imlach, Wendy L., Gmeiner, Peter, Bunnett, Nigel W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235985/
https://www.ncbi.nlm.nih.gov/pubmed/37216510
http://dx.doi.org/10.1073/pnas.2220979120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10235985/
https://www.ncbi.nlm.nih.gov/pubmed/37216510
http://dx.doi.org/10.1073/pnas.2220979120

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