Stem cell decoupling underlies impaired lymphoid development during aging

Mammalian aging is associated with multiple defects of hematopoiesis, most prominently with the impaired development of T and B lymphocytes. This defect is thought to originate in hematopoietic stem cells (HSCs) of the bone marrow, specifically due to the age-dependent accumulation of HSCs with pref...

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Detalles Bibliográficos
Autores principales: Jang, Geunhyo, Contreras Castillo, Stephania, Esteva, Eduardo, Upadhaya, Samik, Feng, Jue, Adams, Nicholas M., Richard, Elodie, Awatramani, Rajeshwar, Sawai, Catherine M., Reizis, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236001/
https://www.ncbi.nlm.nih.gov/pubmed/37216517
http://dx.doi.org/10.1073/pnas.2302019120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236001/
https://www.ncbi.nlm.nih.gov/pubmed/37216517
http://dx.doi.org/10.1073/pnas.2302019120

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