Development and validation of a model gene therapy biodistribution assay for AVGN7 using digital droplet polymerase chain reaction

Biodistribution assays are integral to gene therapy commercialization and have traditionally used real-time qPCR. Droplet digital PCR (ddPCR), however, has distinct advantages including higher sensitivity and absolute quantification but is underused because of lacking regulatory guidance and meaning...

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Detalles Bibliográficos
Autores principales: Rodgers, Buel D., Herring, Sarah K., Carias, Dereck R., Chen, Joyce, Rocha, Agostinho G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236005/
https://www.ncbi.nlm.nih.gov/pubmed/37273901
http://dx.doi.org/10.1016/j.omtm.2023.05.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236005/
https://www.ncbi.nlm.nih.gov/pubmed/37273901
http://dx.doi.org/10.1016/j.omtm.2023.05.007

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