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Development and validation of a model gene therapy biodistribution assay for AVGN7 using digital droplet polymerase chain reaction
Biodistribution assays are integral to gene therapy commercialization and have traditionally used real-time qPCR. Droplet digital PCR (ddPCR), however, has distinct advantages including higher sensitivity and absolute quantification but is underused because of lacking regulatory guidance and meaning...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society of Gene & Cell Therapy
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236005/ https://www.ncbi.nlm.nih.gov/pubmed/37273901 http://dx.doi.org/10.1016/j.omtm.2023.05.007 |