DAB2IP Is a Bifunctional Tumor Suppressor That Regulates Wild-Type RAS and Inflammatory Cascades in KRAS Mutant Colon Cancer

The DAB2IP tumor suppressor encodes a RAS GTPase-activating protein. Accordingly, DAB2IP has been shown to be mutated or suppressed in tumor types that typically lack RAS mutations. However, here we report that DAB2IP is mutated or selectively silenced in the vast majority of KRAS and BRAF mutant co...

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Detalles Bibliográficos
Autores principales: Miller, Abigail L., Perurena, Naiara, Gardner, Alycia, Hinoue, Toshinori, Loi, Patrick, Laird, Peter W., Cichowski, Karen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
https://www.ncbi.nlm.nih.gov/pubmed/36939385
http://dx.doi.org/10.1158/0008-5472.CAN-22-0370

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236151/
https://www.ncbi.nlm.nih.gov/pubmed/36939385
http://dx.doi.org/10.1158/0008-5472.CAN-22-0370

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