Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking

[Image: see text] Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp(3)–sp(3) architectures at remote, yet previously unfunctionalized, methylene sp(3) C–H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp(3)–sp(3) bond formations that are otherwise inaccessible in conventional chain-walking events.