Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking

[Image: see text] Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp(3)–sp(3) architectures at remote, yet previously unfunctionalized, methylene sp(3) C–H sites enabled by the presence of native amides. This protocol is characterized by its mild condit...

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Autores principales: Rodrigalvarez, Jesus, Wang, Hao, Martin, Ruben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236437/
https://www.ncbi.nlm.nih.gov/pubmed/36753384
http://dx.doi.org/10.1021/jacs.2c12915
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author Rodrigalvarez, Jesus
Wang, Hao
Martin, Ruben
author_facet Rodrigalvarez, Jesus
Wang, Hao
Martin, Ruben
author_sort Rodrigalvarez, Jesus
collection PubMed
description [Image: see text] Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp(3)–sp(3) architectures at remote, yet previously unfunctionalized, methylene sp(3) C–H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp(3)–sp(3) bond formations that are otherwise inaccessible in conventional chain-walking events.
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spelling pubmed-102364372023-06-03 Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking Rodrigalvarez, Jesus Wang, Hao Martin, Ruben J Am Chem Soc [Image: see text] Herein, we disclose an interrupted deaminative Ni-catalyzed chain-walking strategy that forges sp(3)–sp(3) architectures at remote, yet previously unfunctionalized, methylene sp(3) C–H sites enabled by the presence of native amides. This protocol is characterized by its mild conditions and wide scope, including challenging substrate combinations. Site-selectivity can be dictated by a judicious choice of the ligand, thus offering an opportunity to enable sp(3)–sp(3) bond formations that are otherwise inaccessible in conventional chain-walking events. American Chemical Society 2023-02-08 /pmc/articles/PMC10236437/ /pubmed/36753384 http://dx.doi.org/10.1021/jacs.2c12915 Text en © 2023 American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Rodrigalvarez, Jesus
Wang, Hao
Martin, Ruben
Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking
title Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking
title_full Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking
title_fullStr Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking
title_full_unstemmed Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking
title_short Native Amides as Enabling Vehicles for Forging sp(3)–sp(3) Architectures via Interrupted Deaminative Ni-Catalyzed Chain-Walking
title_sort native amides as enabling vehicles for forging sp(3)–sp(3) architectures via interrupted deaminative ni-catalyzed chain-walking
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236437/
https://www.ncbi.nlm.nih.gov/pubmed/36753384
http://dx.doi.org/10.1021/jacs.2c12915
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