Cargando…
Sclerostin blockade promotes bone metastases of Wnt‐responsive breast cancer cells
The secreted protein sclerostin is primarily produced by osteocytes and suppresses osteoblast differentiation and function by inhibiting the canonical Wnt signaling pathway. Genetic and pharmacological inhibition of sclerostin has been shown to increase bone formation and an anti‐sclerostin antibody...
| Autores principales: | , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236625/ https://www.ncbi.nlm.nih.gov/pubmed/36840409 http://dx.doi.org/10.1111/cas.15765 |