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LOX-1 mediates inflammatory activation of microglial cells through the p38-MAPK/NF-κB pathways under hypoxic-ischemic conditions

BACKGROUND: Microglial cells play an important role in the immune system in the brain. Activated microglial cells are not only injurious but also neuroprotective. We confirmed marked lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in microglial cells in pathological lesion...

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Detalles Bibliográficos
Autores principales: Aoki, Yoshinori, Dai, Hongmei, Furuta, Fumika, Akamatsu, Tomohisa, Oshima, Takuya, Takahashi, Naoto, Goto, Yu-ichi, Oka, Akira, Itoh, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236821/
https://www.ncbi.nlm.nih.gov/pubmed/37268943
http://dx.doi.org/10.1186/s12964-023-01048-w