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A bifunctional bortezomib-loaded porous nano-hydroxyapatite/alginate scaffold for simultaneous tumor inhibition and bone regeneration
Treatments of osteolytic lesions due to malignant metastasis remain one of the major clinical challenges. The residual tumor cells after surgical resections and an acidic tumor microenvironment are unfavorable for osteogenic induction. Bortezomib (BTZ), a proteasome inhibitor used in chemotherapy, a...
Autores principales: | Chen, Jiafei, Wen, Junru, Fu, Yike, Li, Xiang, Huang, Jie, Guan, Xiaoxu, Zhou, Yi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10236870/ https://www.ncbi.nlm.nih.gov/pubmed/37264410 http://dx.doi.org/10.1186/s12951-023-01940-0 |
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