Structural basis of transcription reduction by a promoter-proximal +1 nucleosome

At active human genes, the +1 nucleosome is located downstream of the RNA polymerase II (RNA Pol II) pre-initiation complex (PIC). However, at inactive genes, the +1 nucleosome is found further upstream, at a promoter-proximal location. Here, we establish a model system to show that a promoter-proxi...

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Detalles Bibliográficos
Autores principales: Abril-Garrido, Julio, Dienemann, Christian, Grabbe, Frauke, Velychko, Taras, Lidschreiber, Michael, Wang, Haibo, Cramer, Patrick
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237034/
https://www.ncbi.nlm.nih.gov/pubmed/37148879
http://dx.doi.org/10.1016/j.molcel.2023.04.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237034/
https://www.ncbi.nlm.nih.gov/pubmed/37148879
http://dx.doi.org/10.1016/j.molcel.2023.04.011

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