Metabolomic and transcriptomic analyses of Fmo5(-/)(- )mice reveal roles for flavin-containing monooxygenase 5 (FMO5) in NRF2-mediated oxidative stress response, unfolded protein response, lipid homeostasis, and carbohydrate and one-carbon metabolism

Flavin-containing monooxygenase 5 (FMO5) is a member of the FMO family of proteins, best known for their roles in the detoxification of foreign chemicals and, more recently, in endogenous metabolism. We have previously shown that Fmo5(-/-) mice display an age-related lean phenotype, with much reduce...

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Detalles Bibliográficos
Autores principales: Phillips, Ian R., Veeravalli, Sunil, Khadayate, Sanjay, Shephard, Elizabeth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237457/
https://www.ncbi.nlm.nih.gov/pubmed/37267233
http://dx.doi.org/10.1371/journal.pone.0286692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10237457/
https://www.ncbi.nlm.nih.gov/pubmed/37267233
http://dx.doi.org/10.1371/journal.pone.0286692

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