Cargando…

Silencing of NOTCH3 Signaling in Meniscus Smooth Muscle Cells Inhibits Fibrosis and Exacerbates Degeneration in a HEYL‐Dependent Manner

The mechanisms of meniscus fibrosis and novel ways to enhance fibrosis is unclear. This work reveals human meniscus fibrosis initiated at E24 weeks. Smooth muscle cell cluster is identified in embryonic meniscus, and the combined analysis with previous data suggests smooth muscle cell in embryonic m...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Hao, Liu, Fangzhou, Lin, Zhencan, Jiang, Zongrui, Wen, Xingzhao, Xu, Jie, Zhang, Zhiqi, Ma, Ruofan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238196/ https://www.ncbi.nlm.nih.gov/pubmed/37026620 http://dx.doi.org/10.1002/advs.202207020

Ejemplares similares

Single-cell RNA-seq analysis identifies meniscus progenitors and reveals the progression of meniscus degeneration
por: Sun, Hao, et al.
Publicado: (2020)

The NOTCH3 Downstream Target HEYL Is Required for Efficient Human Airway Basal Cell Differentiation
por: Bodas, Manish, et al.
Publicado: (2021)

Whole-Transcriptome Sequence of Degenerative Meniscus Cells Unveiling Diagnostic Markers and Therapeutic Targets for Osteoarthritis
por: Jiang, Zongrui, et al.
Publicado: (2021)

Notch3 regulates Mybl2 via HeyL to limit proliferation and tumor initiation in breast cancer
por: Brahim, Sonia, et al.
Publicado: (2023)

Meniscus cell lysate induces mitochondrial dysfunction of fibroblast-like synoviocytes via upregulating ANT3 in osteoarthritis: aNT3 is a potentially important novel mediator and drug target in osteoarthritis
por: Du, Xue, et al.
Publicado: (2023)

The notch target gene HEYL modulates metastasis forming capacity of colorectal cancer patient-derived spheroid cells in vivo
por: Weber, Sarah, et al.
Publicado: (2019)

Sustained expression of HeyL is critical for the proliferation of muscle stem cells in overloaded muscle
por: Fukuda, Sumiaki, et al.
Publicado: (2019)

HEYL Regulates Neoangiogenesis Through Overexpression in Both Breast Tumor Epithelium and Endothelium
por: Han, Liangfeng, et al.
Publicado: (2021)

Partial-Methylated HeyL Promoter Predicts the Severe Illness in Egyptian COVID-19 Patients
por: Fadel, Hewida H., et al.
Publicado: (2022)

Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells
por: Ramadhiani, Risa, et al.
Publicado: (2023)

Panax notoginseng Saponins Attenuate Phenotype Switching of Vascular Smooth Muscle Cells Induced by Notch3 Silencing
por: Liu, Nan, et al.
Publicado: (2015)

Sox9 Inhibits Cochlear Hair Cell Fate by Upregulating Hey1 and HeyL Antagonists of Atoh1
por: Veithen, Mona, et al.
Publicado: (2023)

CADASIL mutations and shRNA silencing of NOTCH3 affect actin organization in cultured vascular smooth muscle cells
por: Tikka, Saara, et al.
Publicado: (2012)

Exosomal lncRNA SCIRT/miR-665 Transferring Promotes Lung Cancer Cell Metastasis through the Inhibition of HEYL
por: Wang, Zhengyang, et al.
Publicado: (2021)

A prediction nomogram for deep venous thrombosis risk in patients undergoing primary total hip and knee arthroplasty: a retrospective study
por: Lin, Zhencan, et al.
Publicado: (2023)

The HeyL-Aromatase Axis Promotes Cancer Stem Cell Properties by Endogenous Estrogen-Induced Autophagy in Castration-Resistant Prostate Cancer
por: Lin, Qimei, et al.
Publicado: (2022)

Notch2 and Notch3 Function Together to Regulate Vascular Smooth Muscle Development
por: Wang, Qingqing, et al.
Publicado: (2012)

Thrombin antithrombin complex concentration as an early predictor of deep vein thrombosis after total hip arthroplasty and total knee arthroplasty
por: Lin, Zhencan, et al.
Publicado: (2022)

Molecular Pathways of Notch Signaling in Vascular Smooth Muscle Cells
por: Boucher, Joshua, et al.
Publicado: (2012)

Functional MRI Mapping of Human Meniscus Functionality and its Relation to Degeneration
por: Nebelung, Sven, et al.
Publicado: (2020)

The Synovium Attenuates Cartilage Degeneration in KOA through Activation of the Smad2/3-Runx1 Cascade and Chondrogenesis-related miRNAs
por: Zhao, Xiaoyi, et al.
Publicado: (2020)

Segregation of striated and smooth muscle lineages by a Notch-dependent regulatory network
por: Applebaum, Mordechai, et al.
Publicado: (2014)

Notch signaling functions in noncanonical juxtacrine manner in platelets to amplify thrombogenicity
por: Chaurasia, Susheel N, et al.
Publicado: (2022)

MRI study of medial meniscus degeneration of osteoarthritic knees with or without posterior root tear
por: Hisashi, Kosuke, et al.
Publicado: (2022)

Effect of Suppression of Rotational Joint Instability on Cartilage and Meniscus Degeneration in Mouse Osteoarthritis Model
por: Arakawa, Kohei, et al.
Publicado: (2022)

Kick it up a notch: Notch signaling and kidney fibrosis
por: Sweetwyne, Mariya T, et al.
Publicado: (2014)

Results of Meniscus Repair for the Hypermobile Medial Meniscus
por: Söylev, Serdar, et al.
Publicado: (2014)

Impact of exacerbations of cystic fibrosis on muscle strength
por: Burtin, Chris, et al.
Publicado: (2013)

Notch4 is activated in endothelial and smooth muscle cells in human brain arteriovenous malformations
por: ZhuGe, Qichuan, et al.
Publicado: (2013)

Characterization of smooth muscle cells from human atherosclerotic lesions and their responses to Notch signaling
por: Davis-Knowlton, Jessica, et al.
Publicado: (2018)

Notch signaling regulates strain-mediated phenotypic switching of vascular smooth muscle cells
por: Karakaya, Cansu, et al.
Publicado: (2022)

Magnesium reduces calcification in bovine vascular smooth muscle cells in a dose-dependent manner
por: Kircelli, Fatih, et al.
Publicado: (2012)

Human colorectal cancer cells induce vascular smooth muscle cell apoptosis in an exocrine manner
por: Li, Wei-Wei, et al.
Publicado: (2017)

Roles of metalloproteinase-3 and aggrecanase 1 and 2 in aggrecan cleavage during human meniscus degeneration
por: Ishihara, Gintaro, et al.
Publicado: (2009)

The morphology and histology study on rabbit degenerated medial meniscus after posterior cruciate ligament rupture
por: Deng, Zhenhan, et al.
Publicado: (2019)

IL-10 ameliorates TNF-α induced meniscus degeneration in mature meniscal tissue in vitro
por: Behrendt, P., et al.
Publicado: (2017)

Relating MR relaxation times of ex vivo meniscus to tissue degeneration through comparison with histopathology
por: Einarsson, Emma, et al.
Publicado: (2020)

Silencing of PKG1 Gene Mimics Effect of Aging and Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on Fibrosis and Salt Sensitivity
por: Fedorova, Olga V., et al.
Publicado: (2023)

Mechanobiology of the Meniscus
por: McNulty, Amy L., et al.
Publicado: (2015)

Discoid Meniscus
por: Ifran, Nadia
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_t7da41ug1ljtlsnm806ijg68bc