Cargando…

An MRTF-A–ZEB1–IRF9 axis contributes to fibroblast–myofibroblast transition and renal fibrosis

Myofibroblasts, characterized by the expression of the matricellular protein periostin (Postn), mediate the profibrogenic response during tissue repair and remodeling. Previous studies have demonstrated that systemic deficiency in myocardin-related transcription factor A (MRTF-A) attenuates renal fi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Qianwen, Shao, Tinghui, Zhu, Yuwen, Zong, Gengjie, Zhang, Junjie, Tang, Shifan, Lin, Yanshan, Ma, Hongzhen, Jiang, Zhifan, Xu, Yong, Wu, Xiaoyan, Zhang, Tao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238398/ https://www.ncbi.nlm.nih.gov/pubmed/37121967 http://dx.doi.org/10.1038/s12276-023-00990-6

Ejemplares similares

Modulating Myofibroblastic Differentiation of Fibroblasts through Actin-MRTF Signaling Axis by Micropatterned Surfaces for Suppressed Implant-Induced Fibrosis
por: Han, Weiju, et al.
Publicado: (2023)

Jmjd3/IRF4 axis aggravates myeloid fibroblast activation and m2 macrophage to myofibroblast transition in renal fibrosis
por: Liang, Hua, et al.
Publicado: (2022)

SIRT6 mediates MRTF-A deacetylation in vascular endothelial cells to antagonize oxLDL-induced ICAM-1 transcription
por: Huang, Shan, et al.
Publicado: (2022)

Arecoline-induced myofibroblast transdifferentiation from human buccal mucosal fibroblasts is mediated by ZEB1
por: Chang, Yu-Chao, et al.
Publicado: (2014)

Blockade of Fibroblast YAP Attenuates Cardiac Fibrosis and Dysfunction Through MRTF-A Inhibition
por: Francisco, Jamie, et al.
Publicado: (2020)

LINC00084/miR-204/ZEB1 Axis Mediates Myofibroblastic Differentiation Activity in Fibrotic Buccal Mucosa Fibroblasts: Therapeutic Target for Oral Submucous Fibrosis
por: Lee, Yu-Hsien, et al.
Publicado: (2021)

Resveratrol suppresses myofibroblast activity of human buccal mucosal fibroblasts through the epigenetic inhibition of ZEB1 expression
por: Chang, Yu-Chao, et al.
Publicado: (2016)

MRTF-A controls myofibroblastic differentiation of human multipotent stromal cells and their tumour-supporting function in xenograft models
por: Werner, Sara, et al.
Publicado: (2019)

Cell Adhesion and Shape Regulate TGF-Beta1-Induced Epithelial-Myofibroblast Transition via MRTF-A Signaling
por: O’Connor, Joseph W., et al.
Publicado: (2013)

Rho-actin signaling to the MRTF coactivators dominates the immediate transcriptional response to serum in fibroblasts
por: Esnault, Cyril, et al.
Publicado: (2014)

HDAC6 Regulates the MRTF-A/SRF Axis and Vascular Smooth Muscle Cell Plasticity
por: Zhang, Mengxue, et al.
Publicado: (2018)

Paracrine HB-EGF signaling reduce enhanced contractile and energetic state of activated decidual fibroblasts by rebalancing SRF-MRTF-TCF transcriptional axis
por: Afzal, Junaid, et al.
Publicado: (2022)

An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy
por: Wu, Teng, et al.
Publicado: (2020)

ZEB2 controls kidney stromal progenitor differentiation and inhibits abnormal myofibroblast expansion and kidney fibrosis
por: Kumar, Sudhir, et al.
Publicado: (2023)

Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis
por: Zhang, Huamin, et al.
Publicado: (2023)

Corrigendum: An MRTF-A–Sp1–PDE5 Axis Mediates Angiotensin-II-Induced Cardiomyocyte Hypertrophy
por: Wu, Teng, et al.
Publicado: (2021)

Fibroblasts, myofibroblasts, and wound contraction
Publicado: (1994)

Fibroblasts and myofibroblasts in wound healing
por: Darby, Ian A, et al.
Publicado: (2014)

IRF6 Is Directly Regulated by ZEB1 and ELF3, and Predicts a Favorable Prognosis in Gastric Cancer
por: Li, Dandan, et al.
Publicado: (2019)

A ZEB1/p53 signaling axis in stromal fibroblasts promotes mammary epithelial tumours
por: Fu, Rong, et al.
Publicado: (2019)

Gene regulation and deregulation by MAL/MRTF coactivators
por: Posern, G
Publicado: (2009)

MRTF: Basic Biology and Role in Kidney Disease
por: Miranda, Maria Zena, et al.
Publicado: (2021)

Mutual dependence of the MRTF–SRF and YAP–TEAD pathways in cancer-associated fibroblasts is indirect and mediated by cytoskeletal dynamics
por: Foster, Charles T., et al.
Publicado: (2017)

ROCK/actin/MRTF signaling promotes the fibrogenic phenotype of fibroblast-like synoviocytes derived from the temporomandibular joint
por: Yokota, Seiji, et al.
Publicado: (2017)

miR‐200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2
por: Liao, Yi‐Wen, et al.
Publicado: (2018)

Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis
por: Yao, Liudi, et al.
Publicado: (2018)

Fibroblast-to-myofibroblast transition in bronchial asthma
por: Michalik, Marta, et al.
Publicado: (2018)

Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts
por: Kepser, Lara-Jane, et al.
Publicado: (2021)

Cell-cell contact and matrix adhesion promote αSMA expression during TGFβ1-induced epithelial-myofibroblast transition via Notch and MRTF-A
por: O’Connor, Joseph W., et al.
Publicado: (2016)

The role of the ZEB1–neuroinflammation axis in CNS disorders
por: Poonaki, Elham, et al.
Publicado: (2022)

MRTF-A can activate Nrf2 to increase the resistance to doxorubicin
por: Xu, Yao, et al.
Publicado: (2016)

Resident Fibroblast MKL1 Is Sufficient to Drive Pro-fibrogenic Response in Mice
por: Huang, Shan, et al.
Publicado: (2022)

Pirfenidone and nintedanib modulate properties of fibroblasts and myofibroblasts in idiopathic pulmonary fibrosis
por: Lehtonen, Siri T., et al.
Publicado: (2016)

EZH2 enhances the differentiation of fibroblasts into myofibroblasts in idiopathic pulmonary fibrosis
por: Xiao, Xiao, et al.
Publicado: (2016)

Properties and Functions of Fibroblasts and Myofibroblasts in Myocardial Infarction
por: Venugopal, Harikrishnan, et al.
Publicado: (2022)

Interference with connective tissue growth factor attenuated fibroblast-to-myofibroblast transition and pulmonary fibrosis
por: Yang, Zhizhou, et al.
Publicado: (2022)

Prevention of bleomycin‐induced lung fibrosis via inhibition of the MRTF/SRF transcription pathway
por: Pawelec, Kendell M., et al.
Publicado: (2022)

Profibrotic epithelial phenotype: a central role for MRTF and TAZ
por: Bialik, Janne Folke, et al.
Publicado: (2019)

MRTF specifies a muscle-like contractile module in Porifera
por: Colgren, J., et al.
Publicado: (2022)

Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis
por: Ronkina, Natalia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_nk7es2qc2kllpvv9le6cnj8h79