Cargando…

Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome

The parathyroid hormone receptor type 1 (PTH1R) is a G protein-coupled receptor that plays key roles in regulating calcium homeostasis and skeletal development via binding the ligands, PTH and PTH-related protein (PTHrP), respectively. Eiken syndrome is a rare disease of delayed bone mineralization...

Descripción completa

Detalles Bibliográficos
Autores principales:	Portales-Castillo, Ignacio, Dean, Thomas, Cheloha, Ross W., Creemer, Brendan A., Vilardaga, Jean-Pierre, Savransky, Sofya, Khatri, Ashok, Jüppner, Harald, Gardella, Thomas J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238420/ https://www.ncbi.nlm.nih.gov/pubmed/37268817 http://dx.doi.org/10.1038/s42003-023-04966-0

Ejemplares similares

OR21-3 Spatial Signaling Bias of a Gain-of-Function PTH1R Mutant Associated with Delayed Ossification in Eiken Syndrome
por: Dean, Thomas, et al.
Publicado: (2022)

Functional Properties of Two Distinct PTH1R Mutants Associated With Either Skeletal Defects or Pseudohypoparathyroidism
por: Portales‐Castillo, Ignacio, et al.
Publicado: (2022)

Biased GPCR signaling by the native parathyroid hormone–related protein 1 to 141 relative to its N-terminal fragment 1 to 36
por: Peña, Karina A., et al.
Publicado: (2022)

Precise druggability of the PTH type 1 receptor
por: Sutkeviciute, Ieva, et al.
Publicado: (2022)

Optimization of PTH/PTHrP Hybrid Peptides to Derive a Long‐Acting PTH Analog (LA‐PTH)
por: Noda, Hiroshi, et al.
Publicado: (2020)

Retromer terminates the generation of cAMP by internalized PTH-receptors
por: Feinstein, Timothy N., et al.
Publicado: (2011)

Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long‐Acting PTH
por: Sato, Tadatoshi, et al.
Publicado: (2021)

Substantially Delayed Maturation of Growth Plate Chondrocytes in “Humanized” PTH1R Mice with the H223R Mutation of Jansen's Disease
por: Reyes, Monica, et al.
Publicado: (2023)

PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond
por: Portales-Castillo, Ignacio, et al.
Publicado: (2022)

Activation of a G protein-coupled receptor through indirect antibody-mediated tethering of ligands
por: Cheloha, Ross W., et al.
Publicado: (2021)

MON-538 Ca(2+)Allostery in PTH-Receptor Signaling
por: White, Alex, et al.
Publicado: (2019)

OR30-3 Structural Basis of Activation and Sustained Signaling by the PTH Receptor
por: Sutkeviciute, Ieva, et al.
Publicado: (2019)

SAT-040 Structural Mechanisms of Parathyroid Hormone (PTH) Binding to Receptor and Regulation of Endosomal Signaling
por: Clark, Lisa, et al.
Publicado: (2019)

Response of different PTH assays to therapy with sevelamer or CaCO(3) and active vitamin D sterols
por: Wesseling-Perry, Katherine, et al.
Publicado: (2009)

Therapeutic Potentials of Dimeric (Cys25)PTH(1–34) Peptide for Osteoporosis and Fracture Healing of the Bones- Buy One, Get One Free
por: Park, Doori, et al.
Publicado: (2021)

OR21-6 AZP-3601, a Long-Acting Parathyroid Hormone (PTH) Analog, Normalizes Blood Calcium in Thyroparathyroidectomized (TPTX) Rats Without Causing Deleterious Changes in Bone
por: Culler, Michael, et al.
Publicado: (2022)

Improved GPCR ligands from nanobody tethering
por: Cheloha, Ross W., et al.
Publicado: (2020)

Homozygous Ser-1 to Pro-1 mutation in parathyroid hormone identified in hypocalcemic patients results in secretion of a biologically inactive pro-hormone
por: Hanna, Patrick, et al.
Publicado: (2023)

OR23-01 The Nonredundant Role Of Beta-Amyloid In Mediating Tonic PTH Secretion In Physiological And Pathological States
por: Tu, Chia-Ling, et al.
Publicado: (2023)

Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo
por: Liu, Shi, et al.
Publicado: (2022)

Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase
por: Gidon, Alexandre, et al.
Publicado: (2014)

Odorant Receptor Desensitization in Insects
por: Guo, Hao, et al.
Publicado: (2017)

Decrease in the expression of the type 1 PTH/PTHrP receptor (PTH1R) on chondrocytes in animals with osteoarthritis
por: Becher, Christoph, et al.
Publicado: (2010)

Inverse correlation of intact PTH, oxidized PTH as well as non-oxidized PTH with 25-hydroxyvitamin D3 in kidney transplant recipients
por: Zuo, Jiao, et al.
Publicado: (2023)

Phosphate and FGF-23
por: Jüppner, Harald
Publicado: (2011)

Molecular Definition of Pseudohypoparathyroidism Variants
por: Jüppner, Harald
Publicado: (2021)

Desensitization Contributes to the Synaptic Response of Gain-of-Function Mutants of the Muscle Nicotinic Receptor
por: Elenes, Sergio, et al.
Publicado: (2006)

Disruption of PTH Receptor 1 in T Cells Protects against PTH-Induced Bone Loss
por: Tawfeek, Hesham, et al.
Publicado: (2010)

The whole-PTH/intact-PTH ratio is a useful predictor of severity of secondary hyperparathyroidism
por: Tanaka, Motoko, et al.
Publicado: (2008)

PTH Hypersecretion Triggered by a GABA(B1) and Ca(2+)-sensing Receptor Heterocomplex in Hyperparathyroidism
por: Chang, Wenhan, et al.
Publicado: (2020)

Semi-synthetic nanobody-ligand conjugates exhibit tunable signaling properties and enhanced transcriptional outputs at neurokinin receptor-1
por: Emidio, Nayara Braga, et al.
Publicado: (2023)

OR07-01 Identification of the First Case of Acquired Autoimmune Parathyroid Hormone (PTH) Resistance Due to PTH1 Receptor (PTH1R) Autoantibodies
por: Mandl, Adel, et al.
Publicado: (2020)

Intraoperative parathyroid hormone (PTH) testing in patients with primary hyperparathyroidism and PTH levels in the normal range
por: Medas, Fabio, et al.
Publicado: (2019)

PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling
por: Subramanian, Hariharan, et al.
Publicado: (2016)

THE IN VITRO DESENSITIZATION OF SENSITIVE CELLS BY TRYPSIN
por: David, John R., et al.
Publicado: (1964)

Hypocalcemia after thyroidectomy: iPTH levels and iPTH decline are predictive? Retrospective cohort study()
por: Cannizzaro, Matteo Angelo, et al.
Publicado: (2018)

Case Report: Inactivating PTH/PTHrP Signaling Disorder Type 1 Presenting With PTH Resistance
por: Demaret, Tanguy, et al.
Publicado: (2022)

Ollier disease
por: Silve, Caroline, et al.
Publicado: (2006)

Cyclooxygenase-2 Suppresses the Anabolic Response to PTH Infusion in Mice
por: Choudhary, Shilpa, et al.
Publicado: (2015)

1,25-Dihydroxyvitamin D(3) regulates furin-mediated FGF23 cleavage
por: Xie, Han, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5s9q9ra6e0o39v3ts0ahhbbp0u