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Light-switchable transcription factors obtained by direct screening in mammalian cells

Optogenetic tools can provide fine spatial and temporal control over many biological processes. Yet the development of new light-switchable protein variants remains challenging, and the field still lacks general approaches to engineering or discovering protein variants with light-switchable biologic...

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Detalles Bibliográficos
Autores principales: Zhu, Liyuan, McNamara, Harold M., Toettcher, Jared E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238501/
https://www.ncbi.nlm.nih.gov/pubmed/37268649
http://dx.doi.org/10.1038/s41467-023-38993-6