Evaluating the use of blood pressure polygenic risk scores across race/ethnic background groups

We assess performance and limitations of polygenic risk scores (PRSs) for multiple blood pressure (BP) phenotypes in diverse population groups. We compare “clumping-and-thresholding” (PRSice2) and LD-based (LDPred2) methods to construct PRSs from each of multiple GWAS, as well as multi-PRS approache...

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Detalles Bibliográficos
Autores principales: Kurniansyah, Nuzulul, Goodman, Matthew O., Khan, Alyna T., Wang, Jiongming, Feofanova, Elena, Bis, Joshua C., Wiggins, Kerri L., Huffman, Jennifer E., Kelly, Tanika, Elfassy, Tali, Guo, Xiuqing, Palmas, Walter, Lin, Henry J., Hwang, Shih-Jen, Gao, Yan, Young, Kendra, Kinney, Gregory L., Smith, Jennifer A., Yu, Bing, Liu, Simin, Wassertheil-Smoller, Sylvia, Manson, JoAnn E., Zhu, Xiaofeng, Chen, Yii-Der Ida, Lee, I-Te, Gu, C. Charles, Lloyd-Jones, Donald M., Zöllner, Sebastian, Fornage, Myriam, Kooperberg, Charles, Correa, Adolfo, Psaty, Bruce M., Arnett, Donna K., Isasi, Carmen R., Rich, Stephen S., Kaplan, Robert C., Redline, Susan, Mitchell, Braxton D., Franceschini, Nora, Levy, Daniel, Rotter, Jerome I., Morrison, Alanna C., Sofer, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238525/
https://www.ncbi.nlm.nih.gov/pubmed/37268629
http://dx.doi.org/10.1038/s41467-023-38990-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238525/
https://www.ncbi.nlm.nih.gov/pubmed/37268629
http://dx.doi.org/10.1038/s41467-023-38990-9

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