Reduced dynamic complexity allows structure elucidation of an excited state of KRAS(G13D)

Localized dynamics of RAS, including regions distal to the nucleotide-binding site, is of high interest for elucidating the mechanisms by which RAS proteins interact with effectors and regulators and for designing inhibitors. Among several oncogenic mutants, methyl relaxation dispersion experiments...

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Detalles Bibliográficos
Autores principales: Chao, Fa-An, Chan, Albert H., Dharmaiah, Srisathiyanarayanan, Schwieters, Charles D., Tran, Timothy H., Taylor, Troy, Ramakrishnan, Nitya, Esposito, Dominic, Nissley, Dwight V., McCormick, Frank, Simanshu, Dhirendra K., Cornilescu, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238545/
https://www.ncbi.nlm.nih.gov/pubmed/37268708
http://dx.doi.org/10.1038/s42003-023-04960-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10238545/
https://www.ncbi.nlm.nih.gov/pubmed/37268708
http://dx.doi.org/10.1038/s42003-023-04960-6

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