Oligonucleotide mapping via mass spectrometry to enable comprehensive primary structure characterization of an mRNA vaccine against SARS-CoV-2

Oligonucleotide mapping via liquid chromatography with UV detection coupled to tandem mass spectrometry (LC-UV-MS/MS) was recently developed to support development of Comirnaty, the world’s first commercial mRNA vaccine which immunizes against the SARS-CoV-2 virus. Analogous to peptide mapping of th...

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Detalles Bibliográficos
Autores principales: Gau, Brian C., Dawdy, Andrew W., Wang, Hanliu Leah, Bare, Bradley, Castaneda, Carlos H., Friese, Olga V., Thompson, Matthew S., Lerch, Thomas F., Cirelli, David J., Rouse, Jason C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239040/
https://www.ncbi.nlm.nih.gov/pubmed/37270636
http://dx.doi.org/10.1038/s41598-023-36193-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239040/
https://www.ncbi.nlm.nih.gov/pubmed/37270636
http://dx.doi.org/10.1038/s41598-023-36193-2

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