A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies

BACKGROUND: Mathematical models of haematopoiesis can provide insights on abnormal cell expansions (clonal dominance), and in turn can guide safety monitoring in gene therapy clinical applications. Clonal tracking is a recent high-throughput technology that can be used to quantify cells arising from...

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Detalles Bibliográficos
Autores principales: Del Core, Luca, Pellin, Danilo, Wit, Ernst C., Grzegorczyk, Marco A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239124/
https://www.ncbi.nlm.nih.gov/pubmed/37268887
http://dx.doi.org/10.1186/s12859-023-05269-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239124/
https://www.ncbi.nlm.nih.gov/pubmed/37268887
http://dx.doi.org/10.1186/s12859-023-05269-1

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