Cargando…
A mixed-effects stochastic model reveals clonal dominance in gene therapy safety studies
BACKGROUND: Mathematical models of haematopoiesis can provide insights on abnormal cell expansions (clonal dominance), and in turn can guide safety monitoring in gene therapy clinical applications. Clonal tracking is a recent high-throughput technology that can be used to quantify cells arising from...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239124/ https://www.ncbi.nlm.nih.gov/pubmed/37268887 http://dx.doi.org/10.1186/s12859-023-05269-1 |