CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression

Certain cellular processes are dose-dependent, requiring specific quantities or stoichiometries of gene products, as exemplified by haploinsufficiency and sex-chromosome dosage compensation. Understanding dosage-sensitive processes requires tools to quantitatively modulate protein abundance. Here we...

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Detalles Bibliográficos
Autores principales: Noviello, Gemma, Gjaltema, Rutger A. F., Schulz, Edda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239436/
https://www.ncbi.nlm.nih.gov/pubmed/37270532
http://dx.doi.org/10.1038/s41467-023-38909-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239436/
https://www.ncbi.nlm.nih.gov/pubmed/37270532
http://dx.doi.org/10.1038/s41467-023-38909-4

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