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CasTuner is a degron and CRISPR/Cas-based toolkit for analog tuning of endogenous gene expression
Certain cellular processes are dose-dependent, requiring specific quantities or stoichiometries of gene products, as exemplified by haploinsufficiency and sex-chromosome dosage compensation. Understanding dosage-sensitive processes requires tools to quantitatively modulate protein abundance. Here we...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239436/ https://www.ncbi.nlm.nih.gov/pubmed/37270532 http://dx.doi.org/10.1038/s41467-023-38909-4 |