Cargando…
CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors
As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language development, social interaction, and repetitive behaviors or inflexible interests. Contactin associated protein like 2 (CNTNAP2), encoding a single transmembrane...
Autores principales: | Zhang, Jing, Cai, Fang, Lu, Renbin, Xing, Xiaoliang, Xu, Lu, Wu, Kunyang, Gong, Zishan, Zhang, Qing, Zhang, Yun, Xing, Mengen, Song, Weihong, Li, Jia-Da |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239753/ https://www.ncbi.nlm.nih.gov/pubmed/37271769 http://dx.doi.org/10.1038/s41392-023-01431-6 |
Ejemplares similares
-
Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation
por: Zhang, Qing, et al.
Publicado: (2023) -
APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression
por: Grimm, Marcus O. W., et al.
Publicado: (2015) -
TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009) -
Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice
por: Xing, Xiaoliang, et al.
Publicado: (2019) -
Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
por: Piao, Yi, et al.
Publicado: (2013)