Cargando…

CNTNAP2 intracellular domain (CICD) generated by γ-secretase cleavage improves autism-related behaviors

As the most prevalent neurodevelopmental disorders in children, autism spectrum disorders (ASD) are characterized by deficits in language development, social interaction, and repetitive behaviors or inflexible interests. Contactin associated protein like 2 (CNTNAP2), encoding a single transmembrane...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jing, Cai, Fang, Lu, Renbin, Xing, Xiaoliang, Xu, Lu, Wu, Kunyang, Gong, Zishan, Zhang, Qing, Zhang, Yun, Xing, Mengen, Song, Weihong, Li, Jia-Da
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239753/ https://www.ncbi.nlm.nih.gov/pubmed/37271769 http://dx.doi.org/10.1038/s41392-023-01431-6

Ejemplares similares

Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation
por: Zhang, Qing, et al.
Publicado: (2023)

APP intracellular domain derived from amyloidogenic β- and γ-secretase cleavage regulates neprilysin expression
por: Grimm, Marcus O. W., et al.
Publicado: (2015)

TMP21 Transmembrane Domain Regulates γ-Secretase Cleavage
por: Pardossi-Piquard, Raphaëlle, et al.
Publicado: (2009)

Suppression of Akt-mTOR pathway rescued the social behavior in Cntnap2-deficient mice
por: Xing, Xiaoliang, et al.
Publicado: (2019)

Mechanism of Intramembrane Cleavage of Alcadeins by γ-Secretase
por: Piao, Yi, et al.
Publicado: (2013)

CCNA collaboration CICD 210-060 official cert guide
por: Valentine, Michael
Publicado: (2016)

γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP)
por: Lessard, Christian B., et al.
Publicado: (2015)

γ-Secretase modulators exhibit selectivity for modulation of APP cleavage but inverse γ-secretase modulators do not
por: Lessard, Christian B., et al.
Publicado: (2020)

Acetylcholinesterase blocks cleavage of APP by γ-secretase in 293 cells and mouse brain
por: Niu, Xin, et al.
Publicado: (2012)

Different transmembrane domains determine the specificity and efficiency of the cleavage activity of the γ-secretase subunit presenilin
por: Schmidt, Fabian C., et al.
Publicado: (2023)

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase
por: Bolduc, David M, et al.
Publicado: (2016)

Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
por: Yan, Yan, et al.
Publicado: (2017)

Monoubiquitination and endocytosis direct γ-secretase cleavage of activated Notch receptor
por: Gupta-Rossi, Neetu, et al.
Publicado: (2004)

Defining the Contribution of CNTNAP2 to Autism Susceptibility
por: Sampath, Srirangan, et al.
Publicado: (2013)

GIGYF1-disturbed IGF-1R recycling: a potential contributor to autism spectrum disorder pathogenesis?
por: Xing, Mengen, et al.
Publicado: (2022)

γ-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes
por: Frånberg, Jenny, et al.
Publicado: (2010)

CNTNAP2: exploring association with autism phenotypes in mice
Publicado: (2011)

Correction: Defining the Contribution of CNTNAP2 to Autism Susceptibility
por: Sampath, Srirangan, et al.
Publicado: (2013)

Degraded tactile coding in the Cntnap2 mouse model of autism
por: Wang, Han Chin, et al.
Publicado: (2023)

TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production
por: Wang, Junfeng, et al.
Publicado: (2015)

γ-Secretase and Presenilin Mediate Cleavage and Phosphorylation of Vascular Endothelial Growth Factor Receptor-1
por: Cai, Jun, et al.
Publicado: (2011)

Modulation of amyloid precursor protein cleavage by γ-secretase activating protein through phase separation
por: Jin, Chen, et al.
Publicado: (2022)

Neuroanatomical Alterations in the CNTNAP2 Mouse Model of Autism Spectrum Disorder
por: Gandhi, Tanya, et al.
Publicado: (2023)

Substrate docking to γ-secretase allows access of γ-secretase modulators to an allosteric site
por: Uemura, Kengo, et al.
Publicado: (2010)

The γ-secretase complex: from structure to function
por: Zhang, Xian, et al.
Publicado: (2014)

Development of a High-Throughput Assay for Screening of γ-Secretase Inhibitor with Endogenous Human, Mouse or Drosophila γ-Secretase
por: Wang, Lie-Feng, et al.
Publicado: (2009)

Structure of the transmembrane domain of human nicastrin-a component of γ-secretase
por: Li, Yan, et al.
Publicado: (2016)

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation
por: Inoue, Eiji, et al.
Publicado: (2009)

The Dyslexia-associated KIAA0319 Protein Undergoes Proteolytic Processing with γ-Secretase-independent Intramembrane Cleavage
por: Velayos-Baeza, Antonio, et al.
Publicado: (2010)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
por: Morishima-Kawashima, Maho
Publicado: (2014)

γ‐Secretase cleavage of the Alzheimer risk factor TREM2 is determined by its intrinsic structural dynamics
por: Steiner, Andrea, et al.
Publicado: (2020)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

γ-Secretase in Alzheimer’s disease
por: Hur, Ji-Yeun
Publicado: (2022)

Dysregulation of Parvalbumin Expression in the Cntnap2−/− Mouse Model of Autism Spectrum Disorder
por: Lauber, Emanuel, et al.
Publicado: (2018)

Altered Cerebellar Response to Somatosensory Stimuli in the Cntnap2 Mouse Model of Autism
por: Fernández, Marta, et al.
Publicado: (2021)

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease
por: Pluta, Ryszard, et al.
Publicado: (2012)

Effects of presenilin-1 familial Alzheimer’s disease mutations on γ-secretase activation for cleavage of amyloid precursor protein
por: Do, Hung N., et al.
Publicado: (2023)

γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing
por: Weber, Tobias A., et al.
Publicado: (2021)

CNTNAP4 deficiency in dopaminergic neurons initiates parkinsonian phenotypes
por: Zhang, Wenlong, et al.
Publicado: (2020)

Structure-function relationship of γ-secretase
por: Tomita, Taisuke
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_49gfe9tg8toc7vpakq93l22ggo