Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis. Here, we explored the anti-cancer effects of the pyruvate kinase (PK) M2 inhibitor...

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Detalles Bibliográficos
Autores principales: Wang, Kaixuan, Lu, Hao, Wang, Xinmiao, Liu, Qingxia, Hu, Jinxia, Liu, Yao, Jin, Meihua, Kong, Dexin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239820/
https://www.ncbi.nlm.nih.gov/pubmed/37284309
http://dx.doi.org/10.3389/fphar.2023.1200538

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239820/
https://www.ncbi.nlm.nih.gov/pubmed/37284309
http://dx.doi.org/10.3389/fphar.2023.1200538

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