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Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC
Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis. Here, we explored the anti-cancer effects of the pyruvate kinase (PK) M2 inhibitor...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10239820/ https://www.ncbi.nlm.nih.gov/pubmed/37284309 http://dx.doi.org/10.3389/fphar.2023.1200538 |