On the design of a constitutively active peptide asparaginyl ligase for facile protein conjugation

Peptide asparaginyl ligases (PALs) are precision tools for peptide cyclization, cell‐surface labelling, protein semisynthesis and protein conjugation. PALs are expressed as inactive proenzymes requiring low pH activation. During activation, a large portion of the cap domain of the proenzyme that cov...

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Detalles Bibliográficos
Autores principales: Chua, Niying, Wong, Yee Hwa, El Sahili, Abbas, Liu, Chuan Fa, Lescar, Julien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240336/
https://www.ncbi.nlm.nih.gov/pubmed/36788723
http://dx.doi.org/10.1002/2211-5463.13575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240336/
https://www.ncbi.nlm.nih.gov/pubmed/36788723
http://dx.doi.org/10.1002/2211-5463.13575

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