PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2

PKA is a downstream effector of many inflammatory mediators that induce pain hypersensitivity by increasing the mechanosensitivity of nociceptive sensory afferent. Here, we examine the molecular mechanism underlying PKA-dependent modulation of the mechanically activated ion channel PIEZO2, which con...

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Detalles Bibliográficos
Autores principales: Schaefer, Irina, Verkest, Clement, Vespermann, Lucas, Mair, Thomas, Voß, Hannah, Zeitzschel, Nadja, Lechner, Stefan G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240422/
https://www.ncbi.nlm.nih.gov/pubmed/37146970
http://dx.doi.org/10.1016/j.jbc.2023.104782

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240422/
https://www.ncbi.nlm.nih.gov/pubmed/37146970
http://dx.doi.org/10.1016/j.jbc.2023.104782

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