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PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2

PKA is a downstream effector of many inflammatory mediators that induce pain hypersensitivity by increasing the mechanosensitivity of nociceptive sensory afferent. Here, we examine the molecular mechanism underlying PKA-dependent modulation of the mechanically activated ion channel PIEZO2, which con...

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Detalles Bibliográficos
Autores principales:	Schaefer, Irina, Verkest, Clement, Vespermann, Lucas, Mair, Thomas, Voß, Hannah, Zeitzschel, Nadja, Lechner, Stefan G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240422/ https://www.ncbi.nlm.nih.gov/pubmed/37146970 http://dx.doi.org/10.1016/j.jbc.2023.104782

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