Hierarchically tumor-activated nanoCRISPR-Cas13a facilitates efficient microRNA disruption for multi-pathway-mediated tumor suppression

Rationale: CRISPR-Cas13a is an efficient tool for robust RNA knockdown with lower off-target effect, which may be a potentially powerful and safe tool for cancer gene therapy. However, therapeutic effect of current cancer gene therapy that targeting monogene was compromised by the multi-mutational s...

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Detalles Bibliográficos
Autores principales: Liu, Xiaowei, Yang, Suleixin, Wang, Li, Wu, Xinyue, Wang, Xinxin, Ou, Chunqing, Yang, Jin, Song, Linjiang, Zhou, Shiyao, Wu, Qinjie, Gong, Changyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240819/
https://www.ncbi.nlm.nih.gov/pubmed/37284454
http://dx.doi.org/10.7150/thno.81776

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240819/
https://www.ncbi.nlm.nih.gov/pubmed/37284454
http://dx.doi.org/10.7150/thno.81776

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