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Hierarchically tumor-activated nanoCRISPR-Cas13a facilitates efficient microRNA disruption for multi-pathway-mediated tumor suppression

Rationale: CRISPR-Cas13a is an efficient tool for robust RNA knockdown with lower off-target effect, which may be a potentially powerful and safe tool for cancer gene therapy. However, therapeutic effect of current cancer gene therapy that targeting monogene was compromised by the multi-mutational s...

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Detalles Bibliográficos
Autores principales:	Liu, Xiaowei, Yang, Suleixin, Wang, Li, Wu, Xinyue, Wang, Xinxin, Ou, Chunqing, Yang, Jin, Song, Linjiang, Zhou, Shiyao, Wu, Qinjie, Gong, Changyang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240819/ https://www.ncbi.nlm.nih.gov/pubmed/37284454 http://dx.doi.org/10.7150/thno.81776

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