7-Ketocholesterol accelerates pancreatic β-cell senescence by inhibiting the SIRT1/CDK4–Rb–E2F1 signaling pathway

Pancreatic β-cell dysfunction is a key factor in the development of type 2 diabetes. Pancreatic β-cell senescence accelerates abnormal glucose metabolism, which decreases insulin secretion and cell regeneration ability, eventually leading to diabetes. A cholesterol oxidation product, 7-ketocholester...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhu, Qiuping, Wang, Wei, Wu, Nan, He, Sunyue, Lin, Xihua, Zhang, Wenjing, Zhou, Jiaqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240968/
https://www.ncbi.nlm.nih.gov/pubmed/37265106
http://dx.doi.org/10.1080/19382014.2023.2219105

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240968/
https://www.ncbi.nlm.nih.gov/pubmed/37265106
http://dx.doi.org/10.1080/19382014.2023.2219105

Ejemplares similares