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7-Ketocholesterol accelerates pancreatic β-cell senescence by inhibiting the SIRT1/CDK4–Rb–E2F1 signaling pathway

Pancreatic β-cell dysfunction is a key factor in the development of type 2 diabetes. Pancreatic β-cell senescence accelerates abnormal glucose metabolism, which decreases insulin secretion and cell regeneration ability, eventually leading to diabetes. A cholesterol oxidation product, 7-ketocholester...

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Detalles Bibliográficos
Autores principales:	Zhu, Qiuping, Wang, Wei, Wu, Nan, He, Sunyue, Lin, Xihua, Zhang, Wenjing, Zhou, Jiaqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240968/ https://www.ncbi.nlm.nih.gov/pubmed/37265106 http://dx.doi.org/10.1080/19382014.2023.2219105

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