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Cell-attribute aware community detection improves differential abundance testing from single-cell RNA-Seq data

Variations of cell-type proportions within tissues could be informative of biological aging and disease risk. Single-cell RNA-sequencing offers the opportunity to detect such differential abundance patterns, yet this task can be statistically challenging due to the noise in single-cell data, inter-s...

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Detalles Bibliográficos
Autores principales: Maity, Alok K., Teschendorff, Andrew E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241145/
https://www.ncbi.nlm.nih.gov/pubmed/37277399
http://dx.doi.org/10.1038/s41467-023-39017-z