Phase I/II sequencing study of azacitidine, epacadostat, and pembrolizumab in advanced solid tumors

BACKGROUND: Indoleamine 2,3-dioxygenase 1 (IDO1), an interferon-inducible enzyme, contributes to tumor immune intolerance. Immune checkpoint inhibition may increase interferon levels; combining IDO1 inhibition with immune checkpoint blockade represents an attractive strategy. Epigenetic agents trigg...

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Detalles Bibliográficos
Autores principales: Luke, Jason J., Fakih, Marwan, Schneider, Charles, Chiorean, E. Gabriela, Bendell, Johanna, Kristeleit, Rebecca, Kurzrock, Razelle, Blagden, Sarah P., Brana, Irene, Goff, Laura W., O’Hayer, Kevin, Geschwindt, Ryan, Smith, Michael, Zhou, Feng, Naing, Aung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241827/
https://www.ncbi.nlm.nih.gov/pubmed/37087488
http://dx.doi.org/10.1038/s41416-023-02267-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241827/
https://www.ncbi.nlm.nih.gov/pubmed/37087488
http://dx.doi.org/10.1038/s41416-023-02267-1

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