ACL and HAT1 form a nuclear module to acetylate histone H4K5 and promote cell proliferation

Acetyl-CoA utilized by histone acetyltransferases (HAT) for chromatin modification is mainly generated by ATP-citrate lyase (ACL) from glucose sources. How ACL locally establishes acetyl-CoA production for histone acetylation remains unclear. Here we show that ACL subunit A2 (ACLA2) is present in nu...

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Detalles Bibliográficos
Autores principales: Xu, Qiutao, Yue, Yaping, Liu, Biao, Chen, Zhengting, Ma, Xuan, Wang, Jing, Zhao, Yu, Zhou, Dao-Xiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241871/
https://www.ncbi.nlm.nih.gov/pubmed/37277331
http://dx.doi.org/10.1038/s41467-023-39101-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241871/
https://www.ncbi.nlm.nih.gov/pubmed/37277331
http://dx.doi.org/10.1038/s41467-023-39101-4

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