Epigenetic suppression of PGC1α (PPARGC1A) causes collateral sensitivity to HMGCR-inhibitors within BRAF-treatment resistant melanomas

While targeted treatment against BRAF(V600E) improve survival for melanoma patients, many will see their cancer recur. Here we provide data indicating that epigenetic suppression of PGC1α defines an aggressive subset of chronic BRAF-inhibitor treated melanomas. A metabolism-centered pharmacological...

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Detalles Bibliográficos
Autores principales: Liang, Jiaxin, Yu, Deyang, Luo, Chi, Bennett, Christopher, Jedrychowski, Mark, Gygi, Steve P., Widlund, Hans R., Puigserver, Pere
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241879/
https://www.ncbi.nlm.nih.gov/pubmed/37277330
http://dx.doi.org/10.1038/s41467-023-38968-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241879/
https://www.ncbi.nlm.nih.gov/pubmed/37277330
http://dx.doi.org/10.1038/s41467-023-38968-7

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