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Bacteriophage therapy against pathological Klebsiella pneumoniae ameliorates the course of primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is characterized by progressive biliary inflammation and fibrosis. Although gut commensals are associated with PSC, their causative roles and therapeutic strategies remain elusive. Here we detect abundant Klebsiella pneumoniae (Kp) and Enterococcus gallinarum in...

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Bibliographic Details
Main Authors: Ichikawa, Masataka, Nakamoto, Nobuhiro, Kredo-Russo, Sharon, Weinstock, Eyal, Weiner, Iddo Nadav, Khabra, Efrat, Ben-Ishai, Noa, Inbar, Dana, Kowalsman, Noga, Mordoch, Ron, Nicenboim, Julian, Golembo, Myriam, Zak, Naomi, Jablonska, Jagoda, Sberro-Livnat, Hila, Navok, Sharon, Buchshtab, Nufar, Suzuki, Takahiro, Miyamoto, Kentaro, Teratani, Toshiaki, Fujimori, Sota, Aoto, Yoshimasa, Konda, Mikiko, Hayashi, Naoki, Chu, Po-Sung, Taniki, Nobuhito, Morikawa, Rei, Kasuga, Ryosuke, Tabuchi, Takaya, Sugimoto, Shinya, Mikami, Yohei, Shiota, Atsushi, Bassan, Merav, Kanai, Takanori
Format: Online Article Text
Language:English
Published: Nature Publishing Group UK 2023
Subjects:
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241881/
https://www.ncbi.nlm.nih.gov/pubmed/37277351
http://dx.doi.org/10.1038/s41467-023-39029-9