Genome-scale CRISPR screen reveals neddylation to contribute to cisplatin resistance of testicular germ cell tumours

BACKGROUND: Type II testicular germ cell tumours (TGCT) are the most prevalent tumours in young men. Patients suffering from cisplatin-resistant TGCTs are facing very poor prognosis demanding novel therapeutic options. Neddylation is a known posttranslational modification mediating many important bi...

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Detalles Bibliográficos
Autores principales: Funke, Kai, Einsfelder, Ulf, Hansen, Aylin, Arévalo, Lena, Schneider, Simon, Nettersheim, Daniel, Stein, Valentin, Schorle, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241889/
https://www.ncbi.nlm.nih.gov/pubmed/37024667
http://dx.doi.org/10.1038/s41416-023-02247-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10241889/
https://www.ncbi.nlm.nih.gov/pubmed/37024667
http://dx.doi.org/10.1038/s41416-023-02247-5

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